Prairie View A&M Panthers are poised for a pivotal football encounter against the Grambling State Tigers on September 27, 2025, at the neutral site of Cotton Bowl Stadium in Dallas, Texas. Both teams come into the game with strong starts to their season; the Panthers hold a balanced record of 2-2, while the Tigers have secured a slightly better position at 3-1.

The coaching match up features new head coach Tremaine Jackson for Prairie View A&M Panthers, against second year head football coach Mickey Joseph of Grambling State Tigers. This game marks another chapter in a historic rivalry where Grambling State holds the upper hand with a series lead of 51-24-1. Despite the overall dominance by the Tigers, the Panthers secured a thrilling victory in their last meeting, winning 36-34 in a grueling five-overtime bout on September 28, 2024.

This upcoming game not only provides an opportunity for Prairie View A&M to tie the season record but also to build on their current win streak against Grambling State. The stage is set for an intense showdown, with both teams eager to demonstrate their abilities in one of the most anticipated games of the season.